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PK 11195
CAS No. 85532-75-8
PK 11195( —— )
Catalog No. M33467 CAS No. 85532-75-8
PK 11195 (RP 52028) is a TSPO ligand for neuroimaging that exhibits significant protection against CoCl2-induced alterations and can be used to study leishmaniasis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamePK 11195
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NoteResearch use only, not for human use.
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Brief DescriptionPK 11195 (RP 52028) is a TSPO ligand for neuroimaging that exhibits significant protection against CoCl2-induced alterations and can be used to study leishmaniasis.
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DescriptionPK 11195 (RP 52028) is a ligand of translocator protein (TSPO), which targets Leishmania chemotherapy, with IC50s of 14.2 μM, 8.2 μM, 3.5 μM for L. amazonensis, L. major and L. braziliensis, respectively.
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In VitroMedian IC50 values for PK 11195 are 14.2 μM for L. amazonensis, 8.2 μM for L. major, and 3.5 μM for L. braziliensis. The selective index value for L. amazonensis is 13.7, indicating the safety of PK 11195 for future testing in mammals. Time-and dose-dependent reductions in the percentage of infected macrophages, the number of parasites per infected macrophage, and the number of viable intracellular parasites are observed. Electron microscopy reveals some morphological alterations suggestive of autophagy. Interestingly, MCP-1 and superoxide levels are reduced in L. amazonensis-infected macrophages treated with PK 11195.
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In Vivo——
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Synonyms——
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PathwayMicrobiology/Virology
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TargetParasite
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RecptorParasite
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Research Area——
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Indication——
Chemical Information
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CAS Number85532-75-8
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Formula Weight352.86
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Molecular FormulaC21H21ClN2O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (70.85 mM; Ultrasonic )
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SMILESCCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Guedes CES, et al. In vitro evaluation of the anti-leishmanial activity and toxicity of PK-11195. Mem Inst Oswaldo Cruz. 2018 Feb 5;113(4):e170345.?
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